Injurious mechanical ventilation affects neuronal activation in ventilated rats
نویسندگان
چکیده
منابع مشابه
Injurious mechanical ventilation affects neuronal activation in ventilated rats
INTRODUCTION Survivors of critical illness often have significant long-term brain dysfunction, and routine clinical procedures like mechanical ventilation (MV) may affect long-term brain outcome. We aimed to investigate the effect of the increase of tidal volume (Vt) on brain activation in a rat model. METHODS Male Sprague Dawley rats were randomized to three groups: 1) Basal: anesthetized un...
متن کاملErratum to: Injurious mechanical ventilation affects neuronal activation in ventilated rats
Unfortunately, the original version of this article [1] contained an error. Affiliation no. 5 had been omitted to be included for the first author, María Elisa Quilez. This has now been corrected. The full list of affiliations for the first author are: María Elisa Quilez 1 CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III. C/ Sinesio Delgado 6, Madrid, 28029, Spain 2 Critical C...
متن کاملAggravation of myocardial dysfunction by injurious mechanical ventilation in LPS-induced pneumonia in rats
BACKGROUND Mechanical ventilation (MV) may cause ventilator-induced lung injury (VILI) and may thereby contribute to fatal multiple organ failure. We tested the hypothesis that injurious MV of lipopolysaccharide (LPS) pre-injured lungs induces myocardial inflammation and further dysfunction ex vivo, through calcium (Ca2+)-dependent mechanism. MATERIALS AND METHODS N = 35 male anesthetized and...
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The mechanical derangements in the acutely injured lung have long been ascribed, in large part, to altered mechanical function at the alveolar level. This has not been directly demonstrated, however, so we investigated the issue in a rat model of overinflation injury. After thoracotomy, rats were mechanically ventilated with either 1) high tidal volume (Vt) or 2) low Vt with periodic deep infla...
متن کاملMechanical ventilation affects alveolar fibrinolysis in LPS-induced lung injury.
The aim of the present study was to determine the effects of mechanical ventilation on alveolar fibrin turnover in lipopolysaccharide (LPS)-induced lung injury. In a randomised controlled trial, Sprague-Dawley rats (n = 61) were allocated to three ventilation groups after intratracheal LPS (Salmonella enteritidis) instillations. Group I animals were subjected to 16 cmH(2)O positive inspiratory ...
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ژورنال
عنوان ژورنال: Critical Care
سال: 2011
ISSN: 1364-8535
DOI: 10.1186/cc10230